CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a
نویسندگان
چکیده
منابع مشابه
CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a
CYP4Fs were first identified as enzymes that catalyze hydroxylation of leukotriene B4 (LTB4). CYP4F18 has an unusual expression in neutrophils and was predicted to play a role in regulating LTB4-dependent inflammation. We compared chemotaxis of wild-type and Cyp4f18 knockout neutrophils using an in vitro assay. There was no significant difference in the chemotactic response to LTB4, but the res...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2015
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2015/250456